Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …

All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

The ubiquitin-dependent proteolytic pathway plays a major role in selective protein
degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin …

UBIQUITINATION of proteins involves the concerted action of the El ubiquitin-activating
enzyme, E2 ubiquitin-conjugating enzymes and E3 ubiquitin–protein 1igases1–3. It has …

Signal-induced activation of the transcription factor NF-κB requires specific phosphorylation
of the inhibitor IκBα and its subsequent proteolytic degradation. Phosphorylation of serine …

Modification of proteins with ubiquitin or ubiquitin-like proteins (UBLs) by means of an E1–
E2–E3 cascade controls many signalling networks,,. Ubiquitin conjugation involves …

Our previous work has shown that, in the yeast Saccharomyces cerevisiae, any of the eight
stabilizing amino-terminal residues confers a long (> 20 h) half-life on a test protein β …

The proteasome is an intracellular enzyme complex that degrades ubiquitin-tagged proteins
and thereby regulates protein levels within the cell. Given this important role in maintaining …

Our previous work has shown that the amino-terminal residue of a short-lived protein is a
distinct component of the protein's degradation signal. To define the complete signal …

Bullous pemphigoid (BP) and herpes gestationis (HG) are skin diseases characterized by
subepidermal blisters and autoantibodies against two hemidesmosomal Ag, ie, BP230 and …