Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent …

The dopamine D2 receptor (D2R) family is upregulated in many cancers and tied to
stemness. Reduced cancer risk has been correlated with disorders such as schizophrenia …

Rationale: A genetic locus within the FAM13A gene has been consistently associated with
chronic obstructive pulmonary disease (COPD) in genome-wide association studies …

Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol
(THC), the psychoactive component in marijuana, increases the risk of developing …

Since its discovery, Wnt signaling has been shown to be one of the most crucial
morphogens in development and during the maturation of central nervous system. Its action …

Exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of
dopaminergic neurons in pancreatic islets has led to controversy regarding the importance …

Parkinson's disease (PD) is primarily characterized by midbrain dopamine depletion.
Dopamine acts through dopamine receptors (D1 to D5) to regulate locomotion, motivation …

Psychiatric disorders such as anxiety, depression and addiction are often comorbid brain
pathologies thought to share common mechanistic biology. As part of the cortico-limbic …

Pimozide, an antipsychotic drug of the diphenylbutylpiperidine class, has been shown to
suppress cell growth of breast cancer cells in vitro. In this study we further explore the …

Dopamine (DA), an important neurotransmitter, has been reported to play a negative role in
tumor progression. DA acts its role via dopamine receptors (DRs), which can be divided into …