Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …

Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Several editions of the World Health Organization (WHO) classifications of lympho‐
hemopoietic neoplasms in 2001, 2008, and 2016 served as the international standard for …

The presence of FLT3 mutations, including the most common FLT3-ITD (internal tandem
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …

Hereditary platelet disorders (HPDs) are a group of blood disorders with variable severity
and clinical impact. Although phenotypically there is much overlap, known genetic causes …

Myelodysplastic syndromes (MDS) are clonal hematologic disorders characterized by
morphologic abnormalities of myeloid cells and peripheral cytopenias. Although genetic …

Biological events that contribute to the pathogenesis of myelodysplastic
syndromes/neoplasms (MDS) are becoming increasingly characterized and are being …

The recent application of whole exome or whole genome sequencing unveiled a plethora of
germline variants predisposing to myeloid disorders, particularly myelodysplastic …

Transformation from chronic (CP) to blast phase (BP) in myeloproliferative neoplasm (MPN)
remains poorly characterized, and no specific mutation pattern has been highlighted. BP …

The diagnosis, classification and treatment of hematopoietic neoplasms requires a precise
definition of the individual entities that configure the broad spectrum of these diseases …