Visualizing intermediate stages of viral membrane fusion by cryo-electron tomography
SM Kephart, N Hom, KK Lee - Trends in Biochemical Sciences, 2024 - cell.com
Protein-mediated membrane fusion is the dynamic process where specialized protein
machinery undergoes dramatic conformational changes that drive two membrane bilayers …
machinery undergoes dramatic conformational changes that drive two membrane bilayers …
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection
X Ren, J Sun, W Kuang, F Yu, B Wang, Y Wang… - Nature …, 2024 - nature.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that
causes severe viral hemorrhagic fever and thrombocytopenia syndrome with a fatality rate of …
causes severe viral hemorrhagic fever and thrombocytopenia syndrome with a fatality rate of …
Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome
S Zhang, H Shang, S Han, J Li, X Peng, Y Wu… - …, 2025 - thelancet.com
Background Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging
tick-borne phlebovirus that causes viral hemorrhagic fever. Pandemic concerns have arisen …
tick-borne phlebovirus that causes viral hemorrhagic fever. Pandemic concerns have arisen …
Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV
P Yang, X Wu, H Shang, Z Sun, Z Wang, Z Song… - PLoS …, 2024 - journals.plos.org
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne
bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high …
bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high …
N-glycosylation of viral glycoprotein is a novel determinant for the tropism and virulence of highly pathogenic tick-borne bunyaviruses
M Shimojima, S Sugimoto, S Taniguchi, T Maeki… - PLoS …, 2024 - journals.plos.org
Severe fever with thrombocytopenia syndrome (SFTS) virus, a tick-borne bunyavirus, causes
a severe/fatal disease termed SFTS; however, the viral virulence is not fully understood. The …
a severe/fatal disease termed SFTS; however, the viral virulence is not fully understood. The …
Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model
Z Chang, D Gao, L Liao, J Sun… - Proceedings of the …, 2024 - National Acad Sciences
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease
with a high fatality rate of up to 30% caused by SFTS virus (SFTSV). However, no specific …
with a high fatality rate of up to 30% caused by SFTS virus (SFTSV). However, no specific …
Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development
D Kim, CJ Lai, I Cha, JU Jung - Viruses, 2024 - mdpi.com
SFTSV is an emerging tick-borne virus causing hemorrhagic fever with a case fatality rate
(CFR) that can reach up to 27%. With endemic infection in East Asia and the recent spread …
(CFR) that can reach up to 27%. With endemic infection in East Asia and the recent spread …
Molecular insight into the neutralization mechanism of human-origin monoclonal antibody AH100 against Hantaan virus
F Wang, T Liu, L Liao, Y Chai, J Qi, F Gao… - Journal of …, 2024 - journals.asm.org
ABSTRACT Both Old World and New World hantaviruses are transmitted through rodents
and can lead to hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary …
and can lead to hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary …
The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly
A Gautam, A Lalande, M Ritter, N Freitas… - Emerging Microbes & …, 2024 - Taylor & Francis
ABSTRACT The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne
bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface …
bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface …
A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective …
J Lu, J Liu, Y Wu, X He, X Gao, X Chen, S Chen… - Journal of …, 2024 - Am Soc Microbiol
Highly pathogenic viruses from family Phenuiviridae, which are mainly transmitted by
arthropods, have intermittently sparked epidemics worldwide. In particular, tick-borne …
arthropods, have intermittently sparked epidemics worldwide. In particular, tick-borne …