Integrins are cell surface receptors that form the link between extracellular matrix molecules
of the cell environment and internal cell signalling and the cytoskeleton. They are involved in …

The Rab family of small GTPases serves as cellular regulators of vesicular transport in all
eukaryotes. Higher organisms have a vastly expanded number of Rabs. Some of these …

The rab11 GTPase has been localized to both the Golgi and recycling endosomes; however,
its Golgi-associated function has remained obscure. In this study, rab11 function in exocytic …

E-cadherin plays an essential role in cell polarity and cell-cell adhesion; however, the
pathway for delivery of E-cadherin to the basolateral membrane of epithelial cells has not …

Recent evidence suggests that apical and basolateral endocytic pathways in epithelia
converge in an apically located, pericentriolar endosomal compartment termed the apical …

We have investigated the trafficking of two endogenous axonal membrane proteins, VAMP2
and NgCAM, in order to elucidate the cellular events that underlie their polarization. We …

The α2δ subunits of voltage-gated calcium channels are important modulatory subunits that
enhance calcium currents and may also have other roles in synaptogenesis. The …

Neurons are highly polarized cells with long neurites. Vesicular transport is required for
neurite extension. We recently identified protrudin as a key regulator of vesicular transport …

Agonist-induced internalization followed by subsequent return to the cell surface regulates G-
protein-coupled receptor (GPCR) activity. Because the cellular responsiveness to ligand …

Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains
unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability …