[HTML][HTML] Multipotent stromal cells: one name, multiple identities
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
regeneration of most tissues. They can differentiate along multiple connective lineages, but …
Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches
Xenotransplantation of patient-derived samples in mouse models has been instrumental in
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …
[HTML][HTML] Gain fat—lose metastasis: converting invasive breast cancer cells into adipocytes inhibits cancer metastasis
D Ishay-Ronen, M Diepenbruck, RKR Kalathur… - Cancer cell, 2019 - cell.com
Cancer cell plasticity facilitates the development of therapy resistance and malignant
progression. De-differentiation processes, such as an epithelial-mesenchymal transition …
progression. De-differentiation processes, such as an epithelial-mesenchymal transition …
Mapping distinct bone marrow niche populations and their differentiation paths
SL Wolock, I Krishnan, DE Tenen, V Matkins… - Cell reports, 2019 - cell.com
The bone marrow microenvironment is composed of heterogeneous cell populations of non-
hematopoietic cells with complex phenotypes and undefined trajectories of maturation …
hematopoietic cells with complex phenotypes and undefined trajectories of maturation …
Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration
AM McDermott, S Herberg, DE Mason… - Science translational …, 2019 - science.org
Large bone defects cannot form a callus and exhibit high complication rates even with the
best treatment strategies available. Tissue engineering approaches often use scaffolds …
best treatment strategies available. Tissue engineering approaches often use scaffolds …
Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation
PM Helbling, E Piñeiro-Yáñez, R Gerosa, S Boettcher… - Cell reports, 2019 - cell.com
Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …
contribute to developmental stage-specific niches, such as those preserving hematopoietic …
Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development
Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however,
the process by which these non-mitotic cells make this transition is not well understood. Prior …
the process by which these non-mitotic cells make this transition is not well understood. Prior …
Matrix metalloproteinase (MMP)-degradable tissue engineered periosteum coordinates allograft healing via early stage recruitment and support of host …
Y Li, MD Hoffman, DSW Benoit - Biomaterials, 2021 - Elsevier
Despite serving as the clinical “gold standard” treatment for critical size bone defects,
decellularized allografts suffer from long-term failure rates of~ 60% due to the absence of the …
decellularized allografts suffer from long-term failure rates of~ 60% due to the absence of the …
Rejuvenating aged osteoprogenitors for bone repair
J Reeves, P Tournier, P Becquart, R Carton, Y Tang… - Elife, 2024 - elifesciences.org
Aging is marked by a decline in tissue regeneration, posing significant challenges to an
increasingly older population. Here, we investigate age-related impairments in calvarial …
increasingly older population. Here, we investigate age-related impairments in calvarial …