RAS is the most frequently mutated oncogene in human cancers, with mutations in about
30% of all cancers. RAS exists in three different isoforms (K-RAS, H-RAS and N-RAS) with …

Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations
identified in human cancer about 3 decades ago. Studies during the last quarter century …

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To
identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were …

The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in
humans are discussed. The principal subjects covered include nitrite-derived alkylating …

The STAT3 transcription factor is an important regulator of stem cell self-renewal, cancer cell
survival, and inflammation. In the pancreas, STAT3 is dispensable for normal development …

The KRAS gene (Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that
encodes a small GTPase transductor protein called KRAS. KRAS is involved in the …

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related
deaths. PDAC remains one of the most difficult-to-treat cancers, owing to its unique …

The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4
complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions …

KRAS is one of the most frequently mutated proto-oncogenes in human cancers. The
dominant oncogenic mutations of KRAS are single amino acid substitutions at codon 12, in …