Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …

Cardiac contractile function is largely mediated by the regulation of Ca2+ cycling throughout
the lifespan. The sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA) pump is paramount …

Neuronatin (NNAT) is a transmembrane protein in the endoplasmic reticulum involved in
metabolic regulation. It shares sequence homology with sarcolipin (SLN), which negatively …

Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates
nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In …

Sarco (endo) plasmic reticulum Ca 2+-ATPase (SERCA) uncoupling in skeletal muscle and
mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue …

Background. Green tea catechins are known to promote mitochondrial function, and to
modulate gene expression and signalling pathways that are altered in the diabetic heart. We …

Despite advances in medicine, cardiac disease remains an increasing health problem
associated with a high mortality rate. Maladaptive cardiac remodeling, such as cardiac …

Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental
gene due to its abundant expression in developing brains. Over the past 25 years …

Disruption of intracellular Ca2+ homeostasis plays an important role as an upstream
pathology in Alzheimer's disease (AD), and correction of Ca2+ dysregulation has been …

Background: Lithium, a commonly used treatment for bipolar disorder, has been shown to
have neuroprotective effects for other conditions including Alzheimer's disease via the …