Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

It has taken four decades of research to see the first major breakthrough for KRAS-driven
cancers. In particular, the last decade has seen a paradigm shift with the discovery of …

The role of KRAS, when activated through canonical mutations, has been well established in
cancer. Here we explore a secondary means of KRAS activation in cancer: focal high-level …

Gastric cancer (GC) is among the most common malignancy in the world with poor
prognosis and limited treatment options. It has been established that gastric carcinogenesis …

Regulatory enhancer elements in solid tumours remain poorly characterized. Here we apply
micro-scale chromatin profiling to survey the distal enhancer landscape of primary gastric …

Gastric cancer is the fifth most incident and the third most common cause of cancer-related
death in the world. Infection with Helicobacter pylori is the major risk factor for this disease …

Gastric cancer (GC) is regarded as the fifth most common cancer and the third cause of
cancer-related deaths worldwide. Mechanism of GC pathogenesis is still unclear and relies …

Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare and aggressive subtype of
gastric cancer. However, little is known about the genomic features of this disease. We …

Despite recent advances in the systemic treatment of gastroesophageal cancers, prognosis
remains poor. Comprehensive molecular analyses have characterized the genomic …

Gastric cancer is a complex disease that is affected by multiple genetic and environmental
factors. For the precise diagnosis and effective treatment of gastric cancer, the heterogeneity …