Several different methods for linkage analysis are shown to arise from a single likelihood
function L for the observed allele-sharing data at multiple markers in a chromosomal region …

With recent rapid advances in mapping of the human genome, including highly polymorphic
and closely linked markers, studies of marker associations with disease are increasingly …

The genes of the human leukocyte antigen (HLA) region, the major histocompatibility
complex (MHC) of humans, control a variety of functions involved in immune response and …

We examined the distribution of non‐B27 alleles of the HLA–B locus among B27+ patients
with ankylosing spondylitis (AS), to detect any additional HLA–B locus allele (s) that may act …

A method is described to reveal the relative predispositional effects (RPEs)(predisposing,
protective, or neutral) of the HLA alleles or of any other marker system that is associated with …

Although essential arterial hypertension is believed to have a strong genetic predisposition,
the gene (s) responsible are unknown. The mechanisms underlying the regulation of blood …

The robust method for detecting linkage developed by Haseman and Elston [The
investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2: 3 …

Proteinuria and nephropathy have been found to cluster in families of non-insulin-
dependent diabetic (NIDDM) Pima Indian, and in Caucasian insulin-dependent diabetic …

To investigate the possible coinheritance of autoimmune diseases that are associated with
the same HLA antigen, we studied 70 families in which at least two siblings had either type I …

We examined the mode of inheritance of rheumatoid arthritis (RA) and estimated the genetic
contribution of the HLA‐linked locus to the development of RA using data from 111 multiplex …