Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays

E Abbotto, B Casini, F Piacente, N Scarano, E Cerri… - Pharmaceuticals, 2023 - mdpi.com
Recently, the development of sirtuin small molecule inhibitors (SIRTIs) has been gaining
attention for the treatment of different cancer types, but also to contrast neurodegenerative …

Genomic Insight of Leishmania Parasite: In-Depth Review of Drug Resistance Mechanisms and Genetic Mutations

K Bharadava, TK Upadhyay, RS Kaushal, I Ahmad… - ACS …, 2024 - ACS Publications
Leishmaniasis, which is caused by a parasitic protozoan of the genus Leishmania, is still a
major threat to global health, impacting millions of individuals worldwide in endemic areas …