Background: The importance of tumour hypoxia for the outcome of radiotherapy has been
under investigation for decades. Numerous clinical trials modifying the hypoxic …

Abstract Ljungkvist, ASE, Bussink, J., Kaanders, JHAM and van der Kogel, AJ Dynamics of
Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers. Radiat. Res. 167, 127 …

In studies of electron and proton radiotherapy, ultrahigh dose rates of FLASH radiotherapy
appear to produce fewer toxicities than standard dose rates while maintaining local tumor …

We investigated whether increasing levels of tissue hypoxia, measured by the binding of
EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide] or by …

Hypoxic tumors are known to be more malignant, to be more likely to metastasize, and to
have a poor prognosis. They are also radio-and chemoresistant. For this reason, it is …

It has been proposed that the generation of O2 during photodynamic therapy (PDT) may
lead to photochemical depletion of ambient tumour oxygen, thus causing acute hypoxia and …

A variety of techniques for measuring oxygen in normal and tumor tissue has been
developed over the years in response to the realization that hypoxia is important in a …

Introduction. Hypoxia induced radioresistance has been acknowledged for decades. One of
the indirect evidences of the influence of hypoxia on radiation response comes from the …

Abstract Pogue, BW, O'Hara, JA, Wilmot, CM, Paulsen, KD and Swartz, HM Estimation of
Oxygen Distribution in RIF-1 Tumors by Diffusion Model-Based Interpretation of …

The notion that invasive cancer is a product of somatic evolution is a well-established theory
that can be modelled mathematically and demonstrated empirically from therapeutic …