Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and
S100A9, was originally discovered as immunogenic protein expressed and secreted by …

Controlled regulation of cell proliferation and differentiation is essential for embryonic
development and requires the coordinated regulation of cell–cell adhesion and gene …

Background Immunotherapy focuses on selectively enhancing the host's immune response
against malignant disease. It has been investigated as an important treatment modality …

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and
so affect protein function and/or stability. PIN1 regulates a number of proteins important for …

The ubiquitin ligase CUL4A has been implicated in tumorigenesis, but its contributions to
progression and metastasis have not been evaluated. Here, we show that CUL4A is …

Recent genetic analyses of paired samples from primary tumours and disseminated tumour
cells have uncovered a bewildering genetic disparity. It was therefore proposed that …

To identify chromosomal aberrations that differentiate among the Dukes' stages of colorectal
cancer (CRC) as well as those that are responsible for the progression into liver metastases …

Array-based comparative genomic hybridization (CGH) allows for the simultaneous
examination of thousands of genomic loci at 1–2 Mb resolution. Copy number alterations …

Aim: Recent studies had suggested substantial molecular differences between tumours from
different ethnic groups. In this study, the molecular differences between the incidences of …