A leucine-rich repeat protein provides a SHOC2 the RAS circuit: a structure-function perspective

JJ Kwon, WC Hahn - Molecular and Cellular Biology, 2021 - Taylor & Francis
ABSTRACT SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream
receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several cellular …

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling

BS Moon, WJ Jeong, J Park, TI Kim… - Journal of the …, 2014 - academic.oup.com
Background Adenomatous polyposis coli (APC) loss-of-function mutations and K-Ras gain-
of-function mutations are common abnormalities that occur during the initiation and …

The leucine‐rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease

HI Jang, P Stevens, T Gao, E Galperin - The FEBS journal, 2021 - Wiley Online Library
Leucine‐rich repeat‐containing proteins (LRR proteins) are involved in supporting a large
number of cellular functions. In this review, we summarize recent advancements in …

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

RM Harmon, CL Simpson, JL Johnson… - The Journal of …, 2013 - Am Soc Clin Investig
Genetic disorders of the Ras/MAPK pathway, termed RASopathies, produce numerous
abnormalities, including cutaneous keratodermas. The desmosomal cadherin, desmoglein-1 …

Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

BS Moon, J Bai, M Cai, C Liu, J Shi, W Lu - Nature communications, 2018 - nature.com
Abstract Kruppel-like factor 4 (Klf4) is a zinc-finger-containing protein that plays a critical role
in diverse cellular physiology. While most of these functions attribute to its role as a …

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells

DW Kang, CY Choi, YH Cho, H Tian… - Journal of Experimental …, 2015 - rupress.org
Expression of the Wnt target gene phospholipase D1 (PLD1) is up-regulated in various
carcinomas, including colorectal cancer (CRC). However, the mechanistic significance of its …

Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer's disease

MY Kim, MJ Kim, C Lee, J Lee, SS Kim… - … & Molecular Medicine, 2023 - nature.com
Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic
strategy for AD. We developed a screening platform, ATRIVIEW®, for molecules that activate …

The function of Shoc2: A scaffold and beyond

ER Jang, E Galperin - Communicative & integrative biology, 2016 - Taylor & Francis
The extracellular signal-regulated kinase (ERK1/2) cascade regulates a myriad of functions
in multicellular organisms. Scaffold proteins provide critical spatial and temporal control over …

[HTML][HTML] Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

S Kaduwal, WJ Jeong, JC Park, KH Lee, YM Lee… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Sur8 (also known as Shoc2) is a Ras-Raf scaffold protein that modulates signaling through
extracellular signal-regulated kinase (ERK) pathway. Although Sur8 has been shown to be a …

[HTML][HTML] Prognostication of early-onset endometrioid endometrial cancer based on genome-wide DNA methylation profiles

T Hirano, E Arai, M Fujimoto, Y Nakayama… - Journal of …, 2022 - ncbi.nlm.nih.gov
Objective The aim of this study was to establish criteria that would indicate whether fertility
preservation therapy would likely be safe for patients aged 40 years or less with …