Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies* |
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Background: Thyrotropin receptor (TSHR) antibodies that stimulate the thyroid (TSAb) cause
Graves' hyperthyroidism and TSHR antibodies which block thyrotropin action (TBAb) are …

Thyroid hormones are vital in metabolism, growth and development. Thyroid hormone
synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR). In …

Kaposi's sarcoma–associated herpesvirus (KSHV) is involved in the development of
lymphoproliferative diseases and Kaposi's sarcoma. The oncogenicity of this virus is …

The application of molecular biology to the study of the thyrotropin receptor (TSHR) has led
to major advances in our understanding of its structure, function, and relationship to the …

The TSH receptor (TSHR) on the surface of thyrocytes is unique among the glycoprotein
hormone receptors in comprising two subunits: an extracellular A-subunit, and a largely …

The resistance to thyrotropin (TSH) action is the disease associated with molecular defects
hampering the adequate transmission of TSH stimulatory signal into thyroid cells. The defect …

Context: In the human thyroid gland, TSH activates both the cAMP and inositol phosphates
(IP) signaling cascades via binding to the TSH receptor (TSHR). Biallelic TSHR loss-of …

Focuses on somatic and germline mutations of the TSH receptor and thyroid diseases.
Proposed scheme for the evolution of radionuclide thyroid scans and thyroid hormone …

T HE INTRODUCTION of generalized iodine prophylaxis in severely iodine-deficient areas
has frequently been followed by the appearance of iodine-induced hyperthyroidism, ie of …