Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview

W Brack, S Ait-Aissa, RM Burgess, W Busch… - Science of the Total …, 2016 - Elsevier
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …

Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects

BI Escher, JLM Hermens - Environmental science & technology, 2002 - ACS Publications
In contrast to the general research attitude in the basic sciences, environmental sciences are
often goal-driven and should provide the scientific basis for risk assessment procedures …

Sorption capacity of plastic debris for hydrophobic organic chemicals

H Lee, WJ Shim, JH Kwon - Science of the total environment, 2014 - Elsevier
The occurrence of microplastics (MPs) in the ocean is an emerging world-wide concern. Due
to high sorption capacity of plastics for hydrophobic organic chemicals (HOCs), sorption may …

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

FA Groothuis, MB Heringa, B Nicol, JLM Hermens… - Toxicology, 2015 - Elsevier
Challenges to improve toxicological risk assessment to meet the demands of the EU
chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have …

[PDF][PDF] Peer reviewed: equilibrium sampling devices

P Mayer, J Tolls, JLM Hermens, D Mackay - 2003 - ACS Publications
Untitled Page 1 Page 2 Equilibrium SAMPLING Devices PHILIPP MAYER NATIONAL
ENVIRONMENTAL RESEARCH INSTITUTE, DENMARK JOHANNES TOLLS HENKEL KGaA …

Polymer selection for passive sampling: A comparison of critical properties

TP Rusina, F Smedes, J Klanova, K Booij, I Holoubek - Chemosphere, 2007 - Elsevier
Next to the bi-phasic semipermeable membrane devices (SPMDs), single-phase passive
samplers are becoming more popular for the sampling of hydrophobic contaminants. We …

[PDF][PDF] Peer reviewed: internal exposure: linking bioavailability to effects

BI Escher, JLM Hermens - 2004 - ACS Publications
Internal Exposure:LINKING BioavailabilitytoEffects Page 1 © 2004 American Chemical
Society DECEMBER 1, 2004 / ENVIRONMENTAL SCIENCE & TECHNOLOGY ■ 455A …

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

S Scholz, E Sela, L Blaha, T Braunbeck… - Regulatory toxicology …, 2013 - Elsevier
Tests with vertebrates are an integral part of environmental hazard identification and risk
assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed …

Review of the partitioning of chemicals into different plastics: consequences for the risk assessment of marine plastic debris

IA O'Connor, L Golsteijn, AJ Hendriks - Marine Pollution Bulletin, 2016 - Elsevier
Marine plastic debris are found worldwide in oceans and coastal areas. They degrade only
slowly and contain chemicals added during manufacture or absorbed from the seawater …

Proposal to improve vertebrate cell cultures to establish them as substitutes for the regulatory testing of chemicals and effluents using fish

K Schirmer - Toxicology, 2006 - Elsevier
Cultures of vertebrate cells are widely applied in mechanistic studies in human toxicology as
well as in toxicity identification in ecotoxicology. As in vitro models, they display many …