Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation
is the canonical model of synaptic plasticity confined to a postnatal critical period …

Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Patients with depression often suffer from cognitive impairments that contribute to disease
burden. We used social defeat–induced persistent stress (SDPS) to induce a depressive-like …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix
(ECM) molecules that compose or interact with PNNs, in the pathophysiology of several …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …