Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal
level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Muscarinic acetylcholine receptors (mAChRs) are G proteincoupled receptors (GPCRs) that
mediate the metabotropic actions of acetylcholine (ACh). There are five subtypes of mAChR …

The medial septum/diagonal band of Broca complex (MSDB) is a key structure that
modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central …

Key points Parvalbumin‐containing (PV) neurons from mouse CA1 hippocampus (HC) and
prefrontal cortex exhibit a fast spiking phenotype in vitro. Within CA1, HC PV cells are mainly …

This article provides a review of the effects of activation of muscarinic and nicotinic receptors
on the physiological properties of circuits in the hippocampal formation. Previous articles …

Hyperactivity within the ventral hippocampus (vHPC) has been linked to both psychosis in
humans and behavioral deficits in animal models of schizophrenia. A local decrease in …

Abstract Cholecystokinin-expressing GABAergic (CCK-GABA) neurons are perisomatic
inhibitory cells that have been argued to regulate emotion and sculpt the network …

Distinct types of GABAergic interneurons target different subcellular domains of pyramidal
cells, thereby shaping pyramidal cell activity patterns. Whether the presynaptic …

Acetylcholine (ACh) signaling underlies specific aspects of cognitive functions and
behaviors, including attention, learning, memory and motivation. Alterations in ACh …