Possibilities and challenges for developing a successful vaccine for leishmaniasis

S Srivastava, P Shankar, J Mishra, S Singh - Parasites & vectors, 2016 - Springer
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Vaccines to prevent leishmaniasis

R Kumar, C Engwerda - Clinical & translational immunology, 2014 - Wiley Online Library
Leishmaniasis is a parasitic disease that encompasses a range of clinical manifestations
affecting people in tropical and subtropical regions of the world. Epidemiological and …

A recombinant chimeric protein-based vaccine containing T-cell epitopes from amastigote proteins and combined with distinct adjuvants, induces immunogenicity and …

DP Lage, DL Vale, FP Linhares, CS Freitas… - Vaccines, 2022 - mdpi.com
Currently, there is no licensed vaccine to protect against human visceral leishmaniasis (VL),
a potentially fatal disease caused by infection with Leishmania parasites. In the current …

Visceral leishmaniasis: advancements in vaccine development via classical and molecular approaches

S Joshi, K Rawat, NK Yadav, V Kumar… - Frontiers in …, 2014 - frontiersin.org
Visceral leishmaniasis (VL) or kala-azar, a vector-borne protozoan disease, shows
endemicity in larger areas of the tropical, subtropical and the Mediterranean countries. WHO …

Current strategies for subunit and genetic viral veterinary vaccine development

A Brun, J Bárcena, E Blanco, B Borrego, D Dory… - Virus research, 2011 - Elsevier
Developing vaccines for livestock provides researchers with the opportunity to perform
efficacy testing in the natural hosts. This enables the evaluation of different strategies …

Immunotherapy for visceral leishmaniasis: A trapeze of balancing counteractive forces

PH Mazire, B Saha, A Roy - International immunopharmacology, 2022 - Elsevier
The protozoan parasite Leishmania donovani, residing and replicating within the cells of the
monocyte-macrophage (mono-mac) lineage, causes visceral leishmaniasis (VL) in humans …

Visceral leishmaniasis: an overview of vaccine adjuvants and their applications

S Ratnapriya, AA Sahasrabuddhe, A Dube - Vaccine, 2019 - Elsevier
Although there has been an extensive research on vaccine development over the last
decade and some vaccines have been commercialized for canine visceral leishmaniasis …

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7 …

J Chandra, JL Dutton, B Li, WP Woo, Y Xu… - Journal of …, 2017 - journals.lww.com
We have previously shown that a novel DNA vaccine technology of codon optimization and
the addition of ubiquitin sequences enhanced immunogenicity of a herpes simplex virus 2 …

DNA vaccine against visceral leishmaniasis: a promising approach for prevention and control

A Kumar, M Samant - Parasite immunology, 2016 - Wiley Online Library
The visceral leishmaniasis (VL) caused by Leishmania donovani parasite severely affects
large populations in tropical and subtropical regions of the world. The arsenal of drugs …

Vaccine Development Against Leishmania donovani

A Das, N Ali - Frontiers in immunology, 2012 - frontiersin.org
Visceral leishmaniasis (VL) caused by Leishmania donovani and Leishmania
infantum/chagasi represents the second most challenging infectious disease worldwide …