[PDF][PDF] Lactoferrin: potential functions, pharmacological insights, and therapeutic promises

KA Ahmed, ASM Saikat, A Moni… - J Adv Biotechnol …, 2021 - pdfs.semanticscholar.org
Lactoferrin (LF) is an iron-binding multifunctional glycoprotein, act as a natural protective
agent. In general, LF is involved in various physiological activities, including antibacterial …

Renoprotective effect of lactoferrin against chromium-induced acute kidney injury in rats: involvement of IL-18 and IGF-1 inhibition

R Hegazy, A Salama, D Mansour, A Hassan - PloS one, 2016 - journals.plos.org
Hexavalent chromium (CrVI) is a heavy metal widely used in more than 50 industries.
Nephrotoxicity is a major adverse effect of chromium poisoning. The present study …

Lactoferrin prevents hepatic injury and fibrosis via the inhibition of NF-κB signaling in a rat non-alcoholic steatohepatitis model

Y Aoyama, A Naiki-Ito, K Xiaochen, M Komura, H Kato… - Nutrients, 2021 - mdpi.com
Non-alcoholic steatohepatitis (NASH) can cause liver cirrhosis and hepatocellular
carcinoma (HCC), with cases increasing worldwide. To reduce the incidence of liver …

[HTML][HTML] The Novel Effect and Potential Mechanism of Lactoferrin on Organ Fibrosis Prevention

Y Yu, J Fang, Y Li, X Wang, J Zhang, J Wang, B Sun - Nutrients, 2025 - mdpi.com
Organ fibrosis is gradually becoming a human health and safety problem, and various
organs of the body are likely to develop fibrosis. The ultimate pathological feature of …

[HTML][HTML] Dendropanax morbifera ameliorates thioacetamide-induced hepatic fibrosis via TGF-β1/Smads pathways

HY Yang, KS Kim, YH Lee, JH Park… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
Hepatic fibrosis, characterized by persistent deposition of extracellular matrix (ECM)
proteins, occurs in most types of chronic liver disease. The prevention of liver damage using …

Alleviative effect of lactoferrin interventions against the hepatotoxicity induced by titanium dioxide nanoparticles

W Zhang, J Sun, F Liu, S Li, X Wang, L Su… - Biological Trace Element …, 2024 - Springer
The current study was designed to investigate the alleviative effect of lactoferrin
interventions against the hepatotoxicity induced by titanium dioxide nanoparticles (TiO2 …

Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: impact on TGF-β/Smad3 and NF-κB signaling pathways

AMH Gowifel, MG Khalil, SA Nada… - Toxicology …, 2020 - Taylor & Francis
Protection against liver injury and its consequences is considered an essential issue to
minimize the number of annual deaths caused by liver diseases. The present study was …

Lupeol inhibits pesticides induced hepatotoxicity via reducing oxidative stress and inflammatory markers in rats

M Coremen, IB Turkyilmaz, H Us, AS Us, S Celik… - Food and Chemical …, 2022 - Elsevier
The present study was aimed at investigating the toxicity of various pesticides on rat liver. It
also aimed to show whether this toxicity could be avoided using lupeol. Adult male Wistars …

Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: Up regulation of hepatic cAMP, and modulation of inflammatory, oxidative …

SA El Awdan, RF Abdel Rahman, HM Ibrahim… - Plos one, 2019 - journals.plos.org
In liver fibrosis, conversion of fibroblasts to profibrogenic myofibroblasts significantly drives
the development of the disease. A crucial role of cyclic adenosine monophosphate (cAMP) …

Lactoferrin relieves Deoxynivalenol-induced oxidative stress and inflammatory response by modulating the Nrf2/MAPK pathways in the liver

P Hu, Y Liu, S Li, Y Zhao, H Gu, Q Zong… - Journal of Agricultural …, 2023 - ACS Publications
Deoxynivalenol (DON), one of the most common mycotoxins contaminating food and feed,
has been shown to induce hepatotoxicity. Lactoferrin (LF) enriched in human milk is a critical …