The functional universe of membrane contact sites

WA Prinz, A Toulmay, T Balla - Nature reviews Molecular cell biology, 2020 - nature.com
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Store-operated calcium channels: from function to structure and back again

RS Lewis - Cold Spring Harbor perspectives in biology, 2020 - cshperspectives.cshlp.org
Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

J Wu, YJ Chen, N Dobbs, T Sakai, J Liou… - Journal of Experimental …, 2019 - rupress.org
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown
mechanisms. Here, we found that these mutants induce chronic activation of ER stress and …

Keep in contact: multiple roles of endoplasmic reticulum–membrane contact sites and the organelle interaction network in plants

P Wang, P Duckney, E Gao, PJ Hussey… - New …, 2023 - Wiley Online Library
Functional regulation and structural maintenance of the different organelles in plants
contribute directly to plant development, reproduction and stress responses. To ensure …

The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites

HA Cohen, E Zomot, T Nataniel, R Militsin, R Palty - Cell Reports, 2023 - cell.com
Depletion of Ca 2+ from the endoplasmic reticulum (ER) causes the ER Ca 2+ sensor STIM1
to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM …

Stay in touch with the endoplasmic reticulum

S Sun, G Zhao, M Jia, Q Jiang, S Li, H Wang… - Science China Life …, 2024 - Springer
The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and
sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it …

Activation mechanisms and structural dynamics of STIM proteins

M Sallinger, H Grabmayr, C Humer… - The Journal of …, 2024 - Wiley Online Library
The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

STIM proteins: an ever-expanding family

H Grabmayr, C Romanin, M Fahrner - International Journal of Molecular …, 2020 - mdpi.com
Stromal interaction molecules (STIM) are a distinct class of ubiquitously expressed single-
pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with …

The role of microtubules in secretory protein transport

L Fourriere, AJ Jimenez, F Perez… - Journal of cell …, 2020 - journals.biologists.com
Microtubules are part of the dynamic cytoskeleton network and composed of tubulin dimers.
They are the main tracks used in cells to organize organelle positioning and trafficking of …

Target molecules of STIM proteins in the central nervous system

K Serwach, J Gruszczynska-Biegala - Frontiers in molecular …, 2020 - frontiersin.org
Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …