Cells adapt to an exposure to xenobiotics by upregulating the biosynthesis of proteins
involved in xenobiotic metabolism. This is achieved largely via activation of cellular …

Abstract Heterocyclic aromatic amines, acrylamide, 5-hydroxymethylfurfural, furan, polycyclic
aromatic hydrocarbons, nitrosamines, acrolein, chloropropanols and chloroesters are …

Abstract Benzo [a] pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon, is widely
present in the environment. BaP-induced heart defects have been frequently reported, but …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …

Uremic metabolites, molecules either produced by the host or from the microbiota population
existing in the gastrointestinal tract that gets excreted by the kidneys into urine, have …

The potential usefulness of silver nanoparticles (AgNPs) in anticancer therapy has been
postulated for many years. However, little is known to date about the exact impact of such …

Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious
adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a …

Pregnane x receptor (PXR) as a nuclear receptor is well-established in drug metabolism,
however, it has pleiotropic functions in regulating inflammatory responses, glucose …

Paclitaxel (PTX) is one of the most efficient drugs for late-stage non-small cell lung cancer
(NSCLC) patients. However, most patients gradually develop resistance to PTX with long …

Pregnancy-related hormones (PRH) have emerged as key regulators of hepatic cytochrome
P450 (CYP) enzyme expression and function. The impact of PRH on protein levels of …