The power of yeast genetics has now been extensively applied to phenotypic variation
among strains of Saccharomyces cerevisiae. As a result, over 100 genes and numerous …

Abstract Model-based design of biological parts is a critical goal of synthetic biology,
especially for eukaryotes. Here we demonstrate that nucleosome architecture can have a …

Gene regulation is a ubiquitous mechanism by which organisms respond to their
environment. While organisms are often found to be adapted to the environments they …

Background New genes that originate from non-coding DNA rather than being duplicated
from parent genes are called de novo genes. Their short evolution time and lack of parent …

Nucleosome positioning plays a key role in the regulation of many biological processes. In
this study, the statistical difference of information content was investigated in nucleosome …

Background Transcriptional regulation of gene expression is usually accomplished by
multiple interactive transcription factors (TFs). Therefore, it is crucial to understand the …

Histone–DNA complexes, so-called nucleosomes, are the building blocks of DNA packaging
in eukaryotic cells. The histone-binding affinity of a local DNA segment depends on its …

Genetic recombination characterized by reciprocal exchange of genes on paired
homologous chromosomes is the most prominent event in meiosis of almost all sexually …

This review focuses on gene transcription patterns of leukemogenic S-phases in mitotic cell
cycles for identification of enzymatic reactions as potential targets for epigenetics-based …

Living systems contain enormous potential to solve many pressing engineering problems,
including the production of usable energy, the synthesis and degradation of a variety of …