Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer
treatment and management. One major contributor to these challenges is epigenetic …

DNA methylation is one of the main epigenetic mechanisms in cancer development and
progression. Aberrant DNA methylation of CpG islands within promoter regions contributes …

Osteosarcoma is a highly malignant bone tumor derived from mesenchymal cells that
contains self-renewing cancer stem cells (CSCs), which are responsible for tumor …

Triple-negative breast cancer (TNBC) is a subtype of breast tumor with the highest breast
cancer stem cells (BCSCs) content and resistance to conventional treatment. Due to the …

Simple Summary Cancer is a distinctly difficult disease to treat on account of the diverse cell
populations/subpopulations that comprise a tumour. Such cells harbour varying genetic and …

Stem cells differentiate into mature organ/tissue-specific cells at a steady pace under normal
conditions, but their growth can be accelerated during the process of tissue healing or in the …

The abnormal expression of human DNA methyltransferases (DNMTs) is closely related with
the occurrence and development of a wide range of human cancers. DNA (cytosine-5) …

Background: Transgelin-2 (TAGLN2) has long been regarded as an actin-binding protein
that modulates actin gelation and controls actin cytoskeleton dynamics. However, recent …

Abstract Triple-Negative Breast Cancer (TNBC), the most common invasive breast cancer,
depicts cancer poor response to conventional therapies. The clinical management of TNBC …