Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …

Mammalian autophagy-related protein Atg8, including the LC3 subfamily and GABARAP
subfamily. Atg8 proteins play a vital role in autophagy initiation, autophagosome formation …

The rising incidence of colistin (COL) resistance poses a significant challenge, undermining
the therapeutic efficacy of COL against life-threatening bacterial infections. Therefore, the …

Hearing loss is one of the most common human diseases, seriously affecting everyday lives.
Mitochondria, as the energy metabolism center in cells, are also involved in regulating active …

In recent years, extensive research has been conducted on the pathogenesis of
sensorineural hearing loss (SNHL). Apoptosis and necrosis have been identified to play …

Colistin used to be regarded as the last-resort treatment for the infection caused by multidrug-
resistant gram-negative bacteria. However, the emergence and widespread of mcr-1 …

Background Methyltransferase-like 3 (METTL3), a component of the N6-methyladenosine
(m6A) methyltransferase family, exhibits significant expression in HEI-OC1 cells and …

The management of hair loss is vital in clinical dermatology due to its prevalence and impact
on patients' quality of life. Quercetin is recognized for its diverse activities, including anti …

Thirteen proteins of oxidative phosphorylation complexes encoded by mitochondrial DNA
(mtDNA) were synthesized by own specific ribosomes (mitoribosomes). Mitoribosomes …

目的· 通过构建线粒体内膜转位酶8A (translocase of inner mitochondrial membrane 8A,
Timm8a) 基因敲除小鼠(即Timm8a-/-小鼠), 探究其听力表型及该基因在内耳的功能. 方法 …