The microbiome in autoimmune diseases

F De Luca, Y Shoenfeld - Clinical & Experimental Immunology, 2019 - academic.oup.com
The microbiome is represented by microorganisms which live in a symbiotic way with the
mammalian. Microorganisms have the ability to influence different physiological aspects …

Metabolic syndrome, autoimmunity and rheumatic diseases

G Medina, O Vera-Lastra, AL Peralta-Amaro… - Pharmacological …, 2018 - Elsevier
Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular (CV) risk factors
including obesity and visceral adiposity, insulin resistance, dyslipidemia and hypertension …

Pathogenic autoreactive T and B cells cross-react with mimotopes expressed by a common human gut commensal to trigger autoimmunity

WE Ruff, C Dehner, WJ Kim, O Pagovich, CL Aguiar… - Cell host & …, 2019 - cell.com
Given the immense antigenic load present in the microbiome, we hypothesized that
microbiota mimotopes can be a persistent trigger in human autoimmunity via cross-reactivity …

[HTML][HTML] Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis

AJ Czaja - World Journal of Gastroenterology, 2016 - ncbi.nlm.nih.gov
The intestinal microbiome is a reservoir of microbial antigens and activated immune cells.
The aims of this review were to describe the role of the intestinal microbiome in generating …

Environmental triggers of autoreactive responses: induction of antiphospholipid antibody formation

A Martirosyan, R Aminov, G Manukyan - Frontiers in immunology, 2019 - frontiersin.org
Antiphospholipid antibodies (aPLs) comprise a diverse family of autoantibodies targeted
against proteins with the affinity toward negatively charged phospholipids or protein …

Identification of a shared microbiomic and metabolomic profile in systemic autoimmune diseases

C Bellocchi, Á Fernández-Ochoa, G Montanelli… - Journal of Clinical …, 2019 - mdpi.com
Dysbiosis has been described in systemic autoimmune diseases (SADs), including systemic
lupus erythematosus (SLE), Sjögren's syndrome (SjS), and primary anti-phosholipid …

[HTML][HTML] The potential role of molecular mimicry by the anaerobic microbiota in the aetiology of autoimmune disease

J English, S Patrick, LD Stewart - Anaerobe, 2023 - Elsevier
Autoimmune diseases are thought to develop as a consequence of various environmental
and genetic factors, each of which contributes to dysfunctional immune responses and/or a …

Incorporating the molecular mimicry of environmental antigens into the causality of autoimmune hepatitis

AJ Czaja - Digestive Diseases and Sciences, 2023 - Springer
Molecular mimicry between foreign and self-antigens has been implicated as a cause of
autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This …

Computational profiling of the gut–brain axis: microflora dysbiosis insights to neurological disorders

N Dovrolis, G Kolios, GM Spyrou… - Briefings in …, 2019 - academic.oup.com
Almost 2500 years after Hippocrates' observations on health and its direct association to the
gastrointestinal tract, a paradigm shift has recently occurred, making the gut and its …

Interaction of intestinal microorganisms with the human host in the framework of autoimmune diseases

B Sánchez, A Hevia, S González… - Frontiers in …, 2015 - frontiersin.org
Autoimmune diseases, such as systemic lupus erythematosus (SLE), are caused by a
complex interaction of environmental-, genetic-, and sex-related factors. Although SLE has …