Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Abstract Interferon-α (IFN-α) has proven to be a clinically effective antiviral and
antineoplastic therapeutic drug for more than 16 years. During this time, evidence from in …

Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the
destruction of infected hepatocytes by CD8+ T lymphocytes. However, in this study, HBV …

The disease state induced by infection with hepatitis B virus (HBV) is manifest in varying
ways characterised by the extent of liver inflammation and damage and viral persistence. In …

Liver transplantation in HBs-antigen (HBsAg) positive allograft recipients is associated with
a high risk of HBV recurrence some time after surgery. So far, results of measures to prevent …

The role of the immune system in liver disease is not only complex but also poorly
understood. Immune disturbances are important causes of liver disease and also play a role …

Constructs expressing the core, surface, X, or polymerase proteins of hepatitis B virus were
transfected into human cells. In transient assays, only the polymerase inhibited the …

The hepatitis B virus (HBV) X gene shares sequences with both the polymerase and precore
genes, carries several regulatory signals critical to the replicative cycle, and its product has a …

Two hundred forty-two voluntary blood donors, referred after detection of HBsAg positivity,
underwent clinical evaluation and liver biopsy and were prospectively followed for an …

Controversy exists regarding major histocompatibility complex antigen expression on
hepatocytes. In this study, hepatocyte expression of class I and II major histocompatibility …