Glycine metabolism in animals and humans: implications for nutrition and health

W Wang, Z Wu, Z Dai, Y Yang, J Wang, G Wu - Amino acids, 2013 - Springer
Glycine is a major amino acid in mammals and other animals. It is synthesized from serine,
threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the …

[HTML][HTML] Glycine: the smallest anti-inflammatory micronutrient

KA Aguayo-Cerón, F Sánchez-Muñoz… - International Journal of …, 2023 - mdpi.com
Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to
specific receptors and transporters that are expressed in many types of cells throughout an …

Dietary glycine is rate-limiting for glutathione synthesis and may have broad potential for health protection

MF McCarty, JH O'Keefe, JJ DiNicolantonio - Ochsner Journal, 2018 - ochsnerjournal.org
Background: Glutathione is a key scavenging antioxidant that opposes the proinflammatory
signaling of hydrogen peroxide. Boosting cellular glutathione levels may have broad utility in …

Glycine suppresses AGE/RAGE signaling pathway and subsequent oxidative stress by restoring Glo1 function in the aorta of diabetic rats and in HUVECs

Z Wang, J Zhang, L Chen, J Li… - … Medicine and Cellular …, 2019 - Wiley Online Library
Oxidative stress plays a crucial role in the pathogenesis of diabetic vascular complications. It
is known that the accumulation of advanced glycation end products (AGEs) and the …

Effects of glycine on metabolic syndrome components: a review

M Imenshahidi, H Hossenzadeh - Journal of Endocrinological …, 2022 - Springer
Purpose Glycine is the simplest and major amino acid in humans. It is mainly generated in
the liver and kidney and is used to produce collagen, creatine, glucose and purine. It is also …

Beneficial effects of the amino acid glycine

I Pérez-Torres, A María Zuniga-Munoz… - Mini reviews in …, 2017 - ingentaconnect.com
Glycine is the smallest non-essential, neutral and metabolically inert amino acid, with a
carbon atom bound to two hydrogen atoms, and to an amino and a carboxyl group. This …

Glucose transport, transporters and metabolism in diabetic retinopathy

C Zhang, L Gu, H Xie, Y Liu, P Huang, J Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Diabetic retinopathy (DR) is the most common reason for blindness in working-age
individuals globally. Prolonged high blood glucose is a main causative factor for DR …

Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure

M Díaz-Flores, M Cruz, G Duran-Reyes… - Canadian journal of …, 2013 - cdnsciencepub.com
Reactive oxygen species derived from abdominal fat and uncontrolled glucose metabolism
are contributing factors to both oxidative stress and the development of metabolic syndrome …

Effect of glycine in streptozotocin-induced diabetic rats

N Alvarado-Vásquez, P Zamudio, E Cerón… - … and Physiology Part C …, 2003 - Elsevier
Inadequate utilization of glucose in diabetes mellitus favors diverse metabolic alterations
that play a relevant role in the physio-pathology of chronic complications of this disease …

[HTML][HTML] A hypothesis from metabolomics analysis of diabetic retinopathy: arginine-creatine metabolic pathway may be a new treatment strategy for diabetic …

Y Sun, L Kong, AH Zhang, Y Han, H Sun… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy is one of the serious complications of diabetes, which the leading
causes of blindness worldwide, and its irreversibility renders the existing treatment methods …