The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …

Rationale: Interstitial lung abnormalities (ILAs) are associated with the highest genetic risk
locus for idiopathic pulmonary fibrosis (IPF); however, the extent to which there are unique …

Objective The first-line chemotherapy for ovarian cancer is based on a combination of
platinum and taxane. To date, no reliable predictive biomarker has been recognized that is …

The Subolesin/Akirin constitutes a good model for the study of functional evolution because
these proteins have been conserved throughout the metazoan and play a role in the …

Introduction: Akirin as a highly conserved transcription factor, exerts a profound influence on
the growth, development, immune response, and reproductive processes in animals. The …

Epithelial immunity protects the host from harmful microbial invaders but also controls the
beneficial microbiota on epithelial surfaces. When this delicate balance between pathogen …

Many host-and vaccine-specific factors modulate an antibody response. Host genetic
polymorphisms, in particular, modulate the immune response in multiple ways on different …

Abstract Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of
various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic …

Akirin is a recently discovered nuclear factor that plays important roles in innate immune
responses. Akirin is a positive regulator of the NF-κB factor of the Drosophila immune …