The prefrontal cortex and OCD

SE Ahmari, SL Rauch - Neuropsychopharmacology, 2022 - nature.com
Abstract Obsessive Compulsive Disorder (OCD) is a highly prevalent and severe
neuropsychiatric disorder, with an incidence of 1.5–3% worldwide. However, despite the …

[HTML][HTML] Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms

JS Soto, Y Jami-Alahmadi, J Chacon, SL Moye… - Nature, 2023 - nature.com
Astrocytes and neurons extensively interact in the brain. Identifying astrocyte and neuron
proteomes is essential for elucidating the protein networks that dictate their respective …

Pediatric acute-onset neuropsychiatric syndrome: Current perspectives

A Gagliano, A Carta, MG Tanca… - … Disease and Treatment, 2023 - Taylor & Francis
Pediatric acute-onset neuropsychiatric syndrome (PANS) features a heterogeneous
constellation of acute obsessive-compulsive disorder (OCD), eating restriction, cognitive …

Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice

JS Soto, C Neupane, M Kaur, V Pandey… - Neuron, 2024 - cell.com
Astrocytes are morphologically complex cells that serve essential roles. They are widely
implicated in central nervous system (CNS) disorders, with changes in astrocyte morphology …

[HTML][HTML] Maternal autoimmunity and inflammation are associated with childhood tics and obsessive-compulsive disorder: transcriptomic data show common enriched …

HF Jones, VX Han, S Patel, BS Gloss, N Soler… - Brain, Behavior, and …, 2021 - Elsevier
Although genetic variation is a major risk factor of neurodevelopmental disorders,
environmental factors during pregnancy and early life are also important in disease …

Inflammation, obsessive-compulsive disorder, and related disorders

J Meyer - The Neurobiology and Treatment of OCD: Accelerating …, 2021 - Springer
Initial reports supporting the possibility of inflammation in the brain in obsessive-compulsive
disorder (OCD) evolved from the models of Sydenham's Chorea, and Pediatric Autoimmune …

Individual differences in stereotypy and neuron subtype translatome with TrkB deletion

M Engeln, Y Song, R Chandra, A La, ME Fox… - Molecular …, 2021 - nature.com
Motor stereotypies occurring in early-onset neuropsychiatric diseases are associated with
dysregulated basal ganglia direct-pathway activity. Disruptions in network connectivity …

Changes in volume of subregions within basal ganglia in obsessive–compulsive disorder: a study with Atlas-based and VBM methods

J Chen, C Tian, Q Zhang, H Xiang, R Wang… - Frontiers in …, 2022 - frontiersin.org
Background The role of basal ganglia in the pathogenesis of obsessive–compulsive
disorder (OCD) remains unclear. The studies on volume changes of basal ganglia in OCD …

Characterizing microRNA editing and mutation sites in Autism Spectrum Disorder

X Wu, H Yang, H Lin, A Suo, S Wu, W Xie… - Frontiers in Molecular …, 2023 - frontiersin.org
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is
still unclear. MicroRNAs (miRNAs) are a kind of endogenous small non-coding RNAs that …

Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder

SC Piantadosi, LL McClain, L Klei, J Wang… - Translational …, 2021 - nature.com
Obsessive-compulsive disorder (OCD) is a chronic and severe psychiatric disorder for which
effective treatment options are limited. Structural and functional neuroimaging studies have …