Positional information and stem cells combine to result in planarian regeneration

PW Reddien - Cold Spring Harbor Perspectives in …, 2022 - cshperspectives.cshlp.org
The capacity for regeneration is broad in the animal kingdom. Planarians are flatworms that
can regenerate any missing body part and their regenerative powers have combined with …

Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression

MD Molina, F Cebrià - Biomolecules, 2021 - mdpi.com
Planarians are flatworms capable of whole-body regeneration, able to regrow any missing
body part after injury or amputation. The extraordinary regenerative capacity of planarians is …

Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance

X Pan, Y Zhao, Y Li, J Chen, W Zhang, L Yang… - Nature …, 2024 - nature.com
Tissue regeneration is a complex process involving large changes in cell proliferation, fate
determination, and differentiation. Mitochondrial dynamics and metabolism play a crucial …

Emerging roles of mitochondria in animal regeneration

Y Zhao, C Gao, X Pan, K Lei - Cell Regeneration, 2023 - Springer
The regeneration capacity after an injury is critical to the survival of living organisms. In
animals, regeneration ability can be classified into five primary types: cellular, tissue, organ …

[HTML][HTML] The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration

JJ Chen, K Lei - Zoological Research, 2023 - ncbi.nlm.nih.gov
Planarians represent the most primitive bilateral triploblastic animals. Most planarian
species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration …

Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians

LL Wong, CG Bruxvoort, NI Cejda, MR Delaney… - Nature …, 2022 - nature.com
Lipid metabolism plays an instructive role in regulating stem cell state and differentiation.
However, the roles of lipid mobilization and utilization in stem cell-driven regeneration are …

Differential Kat3 usage orchestrates the integration of cellular metabolism with differentiation

X Hu, M Ono, NO Chimge, K Chosa, C Nguyen… - Cancers, 2021 - mdpi.com
Simple Summary The coupling of metabolism with cellular status is critically important and
highly evolutionarily conserved. However, how cells coordinate metabolism with …

Poly (A) binding protein 2 is critical for stem cell differentiation during regeneration in the planarian Schmidtea mediterranea

N Mukundan, N Hariharan, V Sasidharan… - Frontiers in Cell and …, 2024 - frontiersin.org
Post-transcriptional regulation has emerged as a key mechanism for regulating stem cell
renewal and differentiation, which is essential for understanding tissue regeneration and …

Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians

X Chen - Heliyon, 2025 - cell.com
Regeneration is the ability to accurately regrow missing body parts. The unparalleled
regenerative capacity and incredible tissue plasticity of planarians, both resulting from the …

Isolation of planarian viable cells using fluorescence‐activated cell sorting for advancing single‐cell transcriptome analysis

Y Kuroki, K Agata - Genes to Cells, 2023 - Wiley Online Library
Preparing viable single cells is critical for conducting single‐cell RNA sequencing (scRNA‐
seq) because the presence of ambient RNA from dead or damaged cells can interfere with …