Ampicillin-controlled glucose metabolism manipulates the transition from tolerance to resistance in bacteria
The mechanism (s) of how bacteria acquire tolerance and then resistance to antibiotics
remains poorly understood. Here, we show that glucose abundance decreases …
remains poorly understood. Here, we show that glucose abundance decreases …
[HTML][HTML] Phenotypic heterogeneity in the bacterial oxidative stress response is driven by cell-cell interactions
Genetically identical bacterial cells commonly display different phenotypes. This phenotypic
heterogeneity is well known for stress responses, where it is often explained as bet hedging …
heterogeneity is well known for stress responses, where it is often explained as bet hedging …
Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement
With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of
treatment to interrupt the progression of MDR-TB to XDR-TB. One way to reduce the …
treatment to interrupt the progression of MDR-TB to XDR-TB. One way to reduce the …
Unrecognized risk of perfluorooctane sulfonate in promoting conjugative transfers of bacterial antibiotic resistance genes
L Yin, X Wang, H Xu, B Yin, X Wang… - Applied and …, 2023 - Am Soc Microbiol
Antibiotic resistance is a major global health crisis facing humanity, with horizontal gene
transfer (HGT) as a principal dissemination mechanism in the natural and clinical …
transfer (HGT) as a principal dissemination mechanism in the natural and clinical …
Reactive oxygen species induced oxidative damage to DNA, lipids, and proteins of antibiotic-resistant bacteria by plant-based silver nanoparticles
This study assesses the mechanism of action of plant-based silver nanoparticles (AgNPs)
against antibiotic-resistant bacteria. We compared AgNPs synthesized through Salvia …
against antibiotic-resistant bacteria. We compared AgNPs synthesized through Salvia …
Genome-wide screen reveals cellular functions that counteract rifampicin lethality in Escherichia coli
Y Wang, H Fu, XJ Shi, GP Zhao, LD Lyu - Microbiology Spectrum, 2024 - Am Soc Microbiol
The antibacterial activity of rifamycins specifically relies on the inhibition of transcription by
directly binding to the β-subunit of bacterial DNA-dependent RNA polymerase (RNAP) …
directly binding to the β-subunit of bacterial DNA-dependent RNA polymerase (RNAP) …
Environmental feedback drives oxidative stress response heterogeneity in bacterial populations
Induction of phenotypic heterogeneity is a ubiquitous consequence of bacterial stress
responses. It is commonly postulated that isogenic cells exploit stochastic molecular …
responses. It is commonly postulated that isogenic cells exploit stochastic molecular …
Cell Death in Escherichia coli: Incomplete Base Excision Repair under Depletion of DapB and Dxr Proteins
RO Azizoglu - Mbio, 2022 - Am Soc Microbiol
The generation of reactive oxygen species (ROS) within the cell is a significantly shared
aspect of bacterial cell death against different stress conditions. The main cell death …
aspect of bacterial cell death against different stress conditions. The main cell death …
Vaccination of Brucella abortus recombinant protein DapB induces CD4+/CD8+ T cells differentiation during Brucella abortus infection in BALB/c mice
Extensive research and testing continue to be conducted for the development of vaccines
targeting zoonotic diseases such as brucellosis. In this study, the potential of the DapB as a …
targeting zoonotic diseases such as brucellosis. In this study, the potential of the DapB as a …
The Effects of Vitamin A and Magnesium Sulfate on the Expression of Nox4 Following Irradiation in Bone Marrow Cells
M Mirdoraghi, S Abbasi - Frontiers in Biomedical …, 2023 - publish.kne-publishing.com
Purpose: Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase is one of the
probable sources of Reactive Oxygen Species generated by ionizing radiation. This study …
probable sources of Reactive Oxygen Species generated by ionizing radiation. This study …