Twenty‐five years ago, in 1998, the HLA Informatics Group of the Anthony Nolan Research
Institute released the IMGT/HLA Database. Since this time, this online resource has acted as …

Immune rejection is an important obstacle to the use of allogeneic 'off-the-shelf'cells for
transplantation into immunocompetent patients. Genetic modification has emerged as a …

Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many
individuals possessing hybrid immunity, generated through a combination of vaccination …

Modern medicine is increasingly focused on personalized medicine, and multi-omics data is
crucial in understanding biological phenomena and disease mechanisms. Each ethnic …

Immunological chaperones tapasin and TAP binding protein, related (TAPBPR) play key
roles in antigenic peptide optimization and quality control of nascent class I major …

Major histocompatibility complex (MHC) proteins present peptides on the cell surface for T
cell surveillance. Reliable in silico prediction of which peptides would be presented and …

T-cell specificity to differentiate between self and non-self relies on T-cell receptor (TCR)
recognition of peptides presented by the Major Histocompatibility Complex (MHC) …

Abstract Purpose of Review To commemorate the 50th anniversary of the groundbreaking
discovery of a remarkably strong association between HLA-B* 27 and ankylosing spondylitis …

A comprehensive knowledge of human leukocyte antigen (HLA) molecular variation
worldwide is essential in human population genetics research and disease association …

The class I proteins of the major histocompatibility complex (MHC-I) display epitopic
peptides derived from endogenous proteins on the cell surface for immune surveillance …