Background Dravet syndrome (DS) is a developmental and epileptic encephalopathy with
onset in the first year of life. At onset, the child displays normal development, but during the …

Dravet syndrome (DS) is a childhood disorder associated with loss-of-function mutations in
SCN1A and is characterized by frequent seizures and severe cognitive impairment. Animal …

Objective Reducing levels of the microtubule‐associated protein tau has shown promise as
a potential treatment strategy for diseases with secondary epileptic features such as …

Abstract SCN1A (Na V 1.1 sodium channel) mutations cause Dravet syndrome (DS) and
GEFS+ (which is in general milder), and are risk factors in other epilepsies. Phenotypic …

Dravet syndrome (DS) is a developmental and epileptic encephalopathy with evolving
disease course as individuals age. In recent years, the treatment landscape of DS has …

Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect
quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a …

Abstract Objective Dravet syndrome (Dravet) is a severe childhood epileptic
encephalopathy. The disease begins with a febrile stage, characterized by febrile seizures …

Background Hippocampal oscillations play a critical role in the ontogeny of allocentric
memory in rodents. During the critical period for memory development, hippocampal theta is …

Mutations in the SCN1A gene, which encodes for the voltage-gated sodium channel NaV1.
1, cause Dravet syndrome, a severe developmental and epileptic encephalopathy. Genetic …

Brain oscillations play a critical role in information processing and may, therefore, be
essential to uncovering the mechanisms of cognitive impairment in neurological disease. In …