Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Engulfment and destruction of invading microorganisms by phagocytosis are critical
components of the innate immune response. In addition, phagocytosis is also required for …

Motile cells extend a leading edge by assembling a branched network of actin filaments that
produces physical force as the polymers grow beneath the plasma membrane. A core set of …

Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …

Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …