As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …

Sjogren's syndrome (SS) is a slowly progressing autoimmune disease, affecting
predominantly middle-aged women, with a female to male ratio reaching 9: 1. It is …

Both type I and II interferons (IFNs) have been implicated in the pathogenesis of Sjogren's
syndrome (SS). We aimed to explore the contribution of type I and II IFN signatures in the …

Sjögren's syndrome (SS) is a chronic autoimmune exocrinopathy associated with variable
degree of lymphocytic infiltration of the affected organs (primarily salivary and lacrimal …

During induction of trained immunity, monocytes and macrophages undergo a functional
and transcriptional reprogramming toward increased activation. Important rewiring of cellular …

Recently recognized as a distinct CD4+ T helper (Th) lineage, Th17 cells have been
implicated in host responses to infections and in pathogenesis associated with autoimmune …

Sjögren's syndrome (SjS) is a systemic autoimmune disease, characterized by the presence
of periductal lymphocytic infiltrations in salivary and lachrymal glands resulting in oral and …

Sjögren's syndrome (SS) or autoimmune epithelitis is a prototype autoimmune disorder with
unique features: a broad clinical spectrum that extends from local exocrinopathy to systemic …

Sjögren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the
function of exocrine glands. The involvement of these glands is characterized by focal …

Sjögren's syndrome (SS) is a systemic progressive autoimmune disease characterized by a
complex pathogenesis requiring a predisposing genetic background and involving immune …