According to the latest report from the World Health Organization, an estimated 265,000
deaths still occur every year as a direct result of burn injuries. A widespread range of these …

Hypoxia and hypoxia signalling through the transcription factor hypoxia inducible factor-1
(HIF-1), play an important role in normal tissue repair processes. Tissue injury generally …

The incidence of chronic wounds is increased among older adults, and the impact of chronic
wounds on quality of life is particularly profound in this population. It is well established that …

Burns are caused by several mechanisms including flame, scald, chemical, electrical, and
ionizing and non-ionizing radiation. Approximately half a million burn cases are registered …

Mesenchymal stem cells (MSCs)‐derived exosomes exhibit protective effects on damaged
or diseased tissues. Hypoxia‐inducible factor 1α (HIF‐1α) plays a critical role in bone …

Hypoxia inducible factors (HIFs) and their regulatory hydroxylases the prolyl hydroxylase
domain enzymes (PHDs) are the key mediators of the cellular response to hypoxia. HIFs are …

The healing of burn wounds has been widely characterized to be highly intricate, involving
processes such as neo-vascularization, granulation, re-epithelialization, inflammation and …

Background Impaired wound healing frequently occurs in diabetes mellitus (DM) and is
implicated in impaired angiogenesis. Long non-coding RNA (lncRNA) H19 has been …

Hypoxia plays a critical role in the development and wound healing process, as well as a
number of pathological conditions. Here, dextran‐based hypoxia‐inducible (Dex‐HI) …

Chronic or non-healing wounds, such as diabetic foot ulcers (DFUs), venous leg ulcers
(VLUs), pressure ulcers (PUs) and wounds in the elderly etc., impose significant biological …