Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity
Alzheimer's disease (AD) is a heterogeneous disorder with abnormalities in multiple
biological domains. In an advanced machine learning analysis of postmortem brain and in …
biological domains. In an advanced machine learning analysis of postmortem brain and in …
Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease
Alzheimer's disease involves many neurobiological alterations from molecular to
macroscopic spatial scales, but we currently lack integrative, mechanistic brain models …
macroscopic spatial scales, but we currently lack integrative, mechanistic brain models …
Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer's disease
Both healthy aging and Alzheimer's disease (AD) are characterized by concurrent
alterations in several biological factors. However, generative brain models of aging and AD …
alterations in several biological factors. However, generative brain models of aging and AD …
Patient-specific multi-modal modeling uncovers neurotransmitter receptor involvement in motor and non-motor axes of Parkinson's disease
Multi-systemic neurodegeneration in Parkinson's disease (PD) is increasingly
acknowledged, involving several neurotransmitter systems beyond the classical …
acknowledged, involving several neurotransmitter systems beyond the classical …
Integrating neurotransmitter receptor architecture in whole-brain computational models of neurodegenerative disease progression
A Khan - 2024 - escholarship.mcgill.ca
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the prevailing causes of
dementia and movement disorder, respectively. These neurodegenerative diseases are …
dementia and movement disorder, respectively. These neurodegenerative diseases are …
[图书][B] Data-driven MRI modelling for the characterization, staging, and subtyping of frontotemporal dementia
J McCarthy - 2021 - search.proquest.com
Frontotemporal dementia (FTD) is a heterogenous neurodegenerative disease
characterized by impairments in behaviour, language, and/or cognition. FTD has a …
characterized by impairments in behaviour, language, and/or cognition. FTD has a …