Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized
capacity to prevent cardiovascular disease events. They inhibit β‐hydroxy β‐methylglutaryl …

Statins lower the serum low-density lipoprotein cholesterol and prevent cardiovascular
events by inhibiting 3-hydroxy-3-methyl-glutaryl-CoA reductase. Although the safety of …

Parkinson's disease (PD) is a major and progressive neurodegenerative disorder, yet the
biological mechanisms involved in its aetiology are poorly understood. Evidence links this …

Mitophagy is a natural phenomenon and entails the lysosomal degradation of mitochondria
by the autophagy pathway. In recent years, the development of fluorescent pH-sensitive …

The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this
study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for …

Tyrosine kinase inhibitors (TKIs) can cause skeletal muscle toxicity in patients, but the
underlying mechanisms are mostly unclear. The goal of the current study was to better …

Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. They are
generally well tolerated, but can cause insulin resistance in patients. Therefore, we …

RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth.
However, monotherapy with glycolysis inhibitors like 2-deoxy-D-glucose causes limited …

Background: Elevated low-density lipoprotein (LDL) cholesterol is a major risk factor for
cardiovascular disease. Statins are the cornerstone of preventing and treating …

Background and Objectives: As is well understood, peroxisome proliferator-activated
receptor gamma cofactor-related 1 (PPRC1) plays a central role in the transcriptional control …