Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Proteins provide the basis for cellular function. Having multiple versions of the same protein
within a single organism provides a way of regulating its activity or developing novel …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

H2A variants are histones that carry out specialized nucleosome function during the
eukaryote genome packaging. Most genes encoding H2A histone variants arose in the …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme in the salvaging
synthesis pathway of the nicotinamide adenine dinucleotide (NAD). Both NAMPT and NAD …

The replacement of replication-coupled histones with non-canonical histone variants
provides chromatin with additional properties and contributes to the plasticity of the …

In addition to replicative histones, eukaryotic genomes encode a repertoire of non-
replicative variant histones, providing additional layers of structural and epigenetic …

In addition to replicative histones, eukaryotic genomes encode a repertoire of non-
replicative variant histones providing additional layers of structural and epigenetic …

TIR domains are central components of pattern recognition immune proteins across all
domains of life. In both bacteria and plants, TIR-domain proteins were shown to recognize …