The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

Conclusion Cardiovascular and cerebrovascular diseases are the most common life-
threatening and debilitating diseases in the industrialized world. However, the incidence …

Obstructive sleep apnea (OSA) is a common medical condition that occurs in approximately
5% to 15% of the population. The pathophysiology of OSA is characterized by repetitive …

In the spontaneously hypertensive (SH) rat, hyperoxic inactivation of the carotid body (CB)
produces a rapid and pronounced fall in both arterial pressure and renal sympathetic nerve …

The chemoreflexes are important modulators of sympathetic activation. The peripheral
chemoreceptors located in the carotid bodies respond primarily to hypoxaemia. Central …

Key points Peripheral chemoreflex sensitivity is enhanced in hypertension yet the role of
these receptors in the development and maintenance of high blood pressure remains …

Background Peripheral chemoreceptor hypersensitivity is a feature of abnormal
cardiorespiratory reflex control in chronic heart failure (CHF) and may contribute to …

Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) is a form of periodic
breathing, commonly observed in patients with heart failure (HF), in which central apneas …

Given that the apnea–ventilation cycle length during central sleep apnea (CSA) with
congestive heart failure (CHF) is∼ 70 s, we hypothesized that rapidly responsive peripheral …