Osteoarthritis of the temporomandibular joint: a narrative overview

C Mélou, P Pellen-Mussi, S Jeanne, A Novella… - Medicina, 2022 - mdpi.com
Background and Objectives: This study reviewed the literature to summarize the current and
recent knowledge of temporomandibular joint osteoarthritis (TMJOA). Methods: Through a …

Extracellular vesicles from M1‐polarized macrophages promote inflammation in the temporomandibular joint via miR‐1246 activation of the Wnt/β‐catenin pathway

S Peng, Y Yan, R Li, H Dai, J Xu - … of the New York Academy of …, 2021 - Wiley Online Library
Macrophage‐mediated regulation of chondrocytes plays an important role in promoting
temporomandibular joint (TMJ) inflammation. We investigated whether extracellular vesicles …

NG2/CSPG4 regulates cartilage degeneration during TMJ osteoarthritis

DA Reed, Y Zhao, M Bagheri Varzaneh… - Frontiers in dental …, 2022 - frontiersin.org
Changes in the mechanical homeostasis of the temporomandibular joint (TMJ) can lead to
the initiation and progression of degenerative arthropathies such as osteoarthritis (OA) …

[HTML][HTML] Disrupting mechanical homeostasis promotes matrix metalloproteinase-13 mediated processing of neuron glial antigen 2 in mandibular condylar cartilage

MB Varzaneh, Y Zhao, J Rozynek, M Han… - European cells & …, 2023 - ncbi.nlm.nih.gov
Post-traumatic osteoarthritis in the temporomandibular joint (TMJ OA) is associated
dysfunctional cell-matrix mediated signalling resulting from changes in the pericellular …

Two-photon fluorescence and second harmonic generation characterization of extracellular matrix remodeling in post-injury murine temporomandibular joint …

DA Reed, M Yotsuya, P Gubareva, PT Toth… - PloS one, 2019 - journals.plos.org
End stage temporomandibular joint osteoarthritis (TMJ-OA) is characterized by fibrillations,
fissures, clefts, and erosion of the mandibular condylar cartilage. The goal of this study was …

Type VI collagen regulates endochondral ossification in the temporomandibular joint

T Komori, Y Ji, H Pham, P Jani, TM Kilts… - Journal of Bone and …, 2022 - academic.oup.com
For many years there has been a keen interest in developing regenerative treatment for
temporomandibular joint–osteoarthritis (TMJ OA). Currently, there is no consensus treatment …

NG2/CSPG4 attenuates motility in mandibular fibrochondrocytes under serum starvation conditions

SY Ahn, M Bagheri Varzaneh, Y Zhao… - Frontiers in Cell and …, 2023 - frontiersin.org
The migration of mandibular fibrochondrocytes is important for the development of the
mandible, the homeostasis of the mandibular cartilage, and for the capacity of the tissue to …

Muscle–bone relationship in temporomandibular joint disorders after partial discectomy

S Ishizuka, M Yamamoto, H Hirouchi, M Yotsuya… - Journal of oral …, 2021 - Elsevier
Objectives Temporomandibular joint osteoarthritis (TMJ-OA) causes degenerative changes
in TMJ tissues. The inter-tissue crosstalk that exacerbates illness and organic changes in …

[HTML][HTML] Post-traumatic osteoarthritic-mediated changes in condylar shape do not covary with changes in the internal microstructure of the bone

Z Skabelund, D Acharya, J Banks, M Chaudhry… - Bone, 2024 - Elsevier
Post-traumatic osteoarthritis (PTOA) in the temporomandibular joint (TMJ) is associated with
remodeling of the subchondral bone. This remodeling changes both the external …

Mechanical loading disrupts focal adhesion kinase activation in mandibular fibrochondrocytes during murine temporomandibular joint osteoarthritis

DA Reed, Y Zhao, M Han, LG Mercuri… - Journal of Oral and …, 2021 - Elsevier
Purpose Mechanical overloading is a key initiating condition for temporomandibular joint
(TMJ) osteoarthritis (OA). The integrin-focal adhesion kinase (FAK) signaling axis is …