Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which
combined represent the largest group of craniofacial malformations in humans with an …

CDH1 encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is
involved in major cellular processes such as embryogenesis and maintenance of tissue …

Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome
characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer …

Non-syndromic cleft lip with or without cleft palate (NS-CL/P) is one of the most common
human birth defects and is generally considered a complex trait. Despite numerous loci …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

The prevalence of gastric cancer (GC) differs among regions worldwide, with the highest
occurrence in east Asia. Thus, its etiology, with respect to ethnic background, environmental …

Orofacial clefts are common developmental disorders that pose significant clinical,
economical and psychological problems. We conducted genome-wide association analyses …

Significant treatment variation exists in the Netherlands between teams treating patients with
cleft lip, alveolus, and/or palate, resulting in a confusing and undesirable situation for …

Non-syndromic cleft lip and/or palate (NSCLP) is a common congenital malformation with a
multifactorial model of inheritance. Although several at-risk alleles have been identified, they …

The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal.
Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about …