[HTML][HTML] Single-molecule visualization of mRNA circularization during translation
Translation is mediated by precisely orchestrated sequential interactions among translation
initiation components, mRNA, and ribosomes. Biochemical, structural, and genetic …
initiation components, mRNA, and ribosomes. Biochemical, structural, and genetic …
The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects
L Krause, F Willing, AZ Andreou… - Nucleic Acids …, 2022 - academic.oup.com
Translation initiation in eukaryotes starts with the recognition of the mRNA 5′-cap by eIF4F,
a hetero-trimeric complex of eIF4E, the cap-binding protein, eIF4A, a DEAD-box helicase …
a hetero-trimeric complex of eIF4E, the cap-binding protein, eIF4A, a DEAD-box helicase …
Smart-ORF: a single-molecule method for accessing ribosome dynamics in both upstream and main open reading frames
A Gaba, H Wang, T Fortune, X Qu - Nucleic Acids Research, 2021 - academic.oup.com
Upstream open reading frame (uORF) translation disrupts scanning 43S flux on mRNA and
modulates main open reading frame (mORF) translation efficiency. Current tools, however …
modulates main open reading frame (mORF) translation efficiency. Current tools, however …
[HTML][HTML] Translational buffering by ribosome stalling in upstream open reading frames
TA Bottorff, H Park, AP Geballe… - PLoS genetics, 2022 - journals.plos.org
Upstream open reading frames (uORFs) are present in over half of all human mRNAs.
uORFs can potently regulate the translation of downstream open reading frames through …
uORFs can potently regulate the translation of downstream open reading frames through …
An in vitro single-molecule imaging assay for the analysis of Cap-dependent translation kinetics
A Gaba, H Wang, X Qu - JoVE (Journal of Visualized Experiments), 2020 - jove.com
Cap-dependent protein synthesis is the predominant translation pathway in eukaryotic cells.
While various biochemical and genetic approaches have allowed extensive studies of cap …
While various biochemical and genetic approaches have allowed extensive studies of cap …
Stable m7G Cap-Distal 5′UTR Hairpin Structure Mediates Distinct 40S and 60S Binding Dynamics
H Wang, A Gaba, X Qu - bioRxiv, 2021 - biorxiv.org
ABSTRACT The 5′ untranslated region (UTR) of diverse mRNAs contains secondary
structures that can influence protein synthesis by modulating the initiation step of translation …
structures that can influence protein synthesis by modulating the initiation step of translation …
m7G cap-eIF4E interaction stimulates polysome formation by enhancing first-round initiation kinetics
L Sun, A Gaba, H Wang, X Qu - bioRxiv, 2021 - biorxiv.org
Translation in eukaryotic cells occurs predominantly through a 7-methylguanosine (m7G)
cap-dependent mechanism. m7G cap interactions with eukaryotic initiation factor 4E (eIF4E) …
cap-dependent mechanism. m7G cap interactions with eukaryotic initiation factor 4E (eIF4E) …
[图书][B] The Role of eIF4E/4E-BP2 Dependent Translation in Epileptic Seizure
D Lou - 2022 - search.proquest.com
In the central nervous system, gene expression is tightly controlled spatiotemporally for
proper brain development and homeostasis. The mammalian/mechanistic target of …
proper brain development and homeostasis. The mammalian/mechanistic target of …