Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell
exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing …

Dendritic cells (DCs) of the cDC2 lineage initiate allergic immunity and in the dermis are
marked by their expression of CD301b. CD301b+ dermal DCs respond to allergens …

Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …

Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …

A previously unappreciated cell type of the innate immune system, termed innate lymphoid
cells (ILCs), has been characterized in mice and humans and found to influence the …

Abstract Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during
type 2 immune responses, are critical for protective immunity against infections of …

There have been substantial advances in cancer diagnostics and therapies in the past
decade. Besides chemotherapeutic agents and radiation therapy, approaches now include …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …