Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …

In part due to the resilience of cellular feedback pathways that develop therapeutic
resistance to targeting the EGFR alone, using EGFR inhibitors alone was demonstrated to …

Antibacterial compounds that reduce extracellular polymeric substances (EPS) are needed
to avoid bacterial biofilms in water pipelines. Herein, green one-pot synthesis of α …

This work describes the design and synthesis of new hybrids of thienopyrimidine and
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …

A series of new coumarin-N-heterocyclic hybrids, coumarin-quinolines 7a–e, coumarin-
acridines 10b, c and coumarin-neocryptolepines 13b, c were synthesized and evaluated for …

Isatin–quinoline conjugates 10a–f and 11a–f were assembled by the reaction of N-
(bromobutyl) isatin derivatives 3a, b with aminoquinolines 6a–c and their corresponding …

The study evaluated the antitumor efficacy of APAN,“synthesized indoloquinoline analog
derived from the parent neocryptolepine isolated from the roots of Cryptolepis …

Newly synthesized mono-and bis-thioureidophosphonate (MTP and BTP) analogues in eco-
friendly conditions were employed as reducing/capping cores for 100, 500, and 1000 mg L …

Thienopyrimidines are an emerging class of fused pyrimidines due to their broad spectrum
of pharmacological properties, including antimicrobial, anti-inflammatory, antimalarial …