Chalcone: a promising bioactive scaffold in medicinal chemistry
G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Multi-targets: An unconventional drug development strategy for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that eventually leads
to dementia and death of the patient. Despite the enormous amounts of resources and …
to dementia and death of the patient. Despite the enormous amounts of resources and …
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
W Liu, M He, Y Li, Z Peng, G Wang - Journal of enzyme inhibition …, 2022 - Taylor & Francis
Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …
Non-alkaloid cholinesterase inhibitory compounds from natural sources
Alzheimer's disease (AD) is a severe neurodegenerative disorder of different brain regions
accompanied by distresses and affecting more than 25 million people in the world. This …
accompanied by distresses and affecting more than 25 million people in the world. This …
Hydroxy chalcones and analogs with chemopreventive properties
The aim of this review is to highlight the chemopreventive properties of hydroxy-substituted
natural and synthetic chalcones along with a number of their analogs. These products …
natural and synthetic chalcones along with a number of their analogs. These products …
An overview of NRF2-activating compounds bearing α, β-unsaturated moiety and their antioxidant effects
MC Egbujor, B Buttari, E Profumo… - International Journal of …, 2022 - mdpi.com
The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …
[HTML][HTML] Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors
Overactivated NLRP3 inflammasome has been shown to associate with an increasing
number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1 …
number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1 …
New Benzodihydrofuran Derivatives Alter the Amyloid β Peptide Aggregation: Strategies To Develop New Anti-Alzheimer Drugs
Y Sánchez, C Castillo, J Fuentealba… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease is a neurodegenerative disorder that is the leading cause of dementia
in elderly patients. Amyloid-β peptide (1–42 oligomers) has been identified as a neurotoxic …
in elderly patients. Amyloid-β peptide (1–42 oligomers) has been identified as a neurotoxic …
Novel 1, 2, 4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study
TS Ibrahim, AJ Almalki, AH Moustafa, RM Allam… - Bioorganic …, 2021 - Elsevier
New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …