Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

With respect to structural and functional cardiac disorders, heart failure (HF) is divided into
HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) …

Human protein kinase C (PKC) isoforms have been implicated in diseases such as
Alzheimer's, diabetes and cancers. In contrast to mammals, which have at least nine genes …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …

The protein kinase C (PKC) and closely related protein kinase N (PKN) families of
serine/threonine protein kinases play crucial cellular roles. Both kinases belong to the AGC …

Protein kinase C (PKC) is a family of serine/threonine protein kinases that play an important
role in many organs and systems and whose activation contributes significantly to …

Sudden cardiac death (SCD) is among the leading causes of death worldwide, and it
remains a public health problem, as it involves young subjects. Current guideline-directed …

Ischemia and reperfusion (I/R) cause a reduction in arterial blood supply to tissues, followed
by the restoration of perfusion and consequent reoxygenation. The reestablishment of blood …

A few decades ago, cardiac muscle was discovered to possess signalling pathways that,
when activated, protect the myocardium against the damage induced by ischaemia …

Maintenance of the highly organized striated muscle tissue requires a cell-wide dynamic
network through protein-protein interactions providing an effective mechanochemical …