Neuroprotective phytochemicals in experimental ischemic stroke: mechanisms and potential clinical applications

H Xu, E Wang, F Chen, J Xiao… - Oxidative Medicine and …, 2021 - Wiley Online Library
Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

Role of polyphenols as antioxidant supplementation in ischemic stroke

Y Zhou, S Zhang, X Fan - Oxidative medicine and cellular …, 2021 - Wiley Online Library
Stroke is the second most common cause of death globally and the leading cause of death
in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress …

Lipocalin-2 may produce damaging effect after cerebral ischemia by inducing astrocytes classical activation

N Zhao, X Xu, Y Jiang, J Gao, F Wang, X Xu… - Journal of …, 2019 - Springer
Background Functions of astrocytes in the rehabilitation after ischemic stroke, especially
their impacts on inflammatory processes, remain controversial. This study uncovered two …

[HTML][HTML] Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal …

Y Li, JJ Zhang, RJ Chen, L Chen, S Chen… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Oxidative stress and neuroinflammation play crucial roles in the progression of
neonatal hypoxic-ischemic brain damage (HIBD). Genistein, a natural phytoestrogen, has …

From preclinical stroke models to humans: Polyphenols in the prevention and treatment of stroke

E Parrella, C Gussago, V Porrini, M Benarese, M Pizzi - Nutrients, 2020 - mdpi.com
Polyphenols are an important family of molecules of vegetal origin present in many
medicinal and edible plants, which represent important alimentary sources in the human …

Genistein protects epilepsy-induced brain injury through regulating the JAK2/STAT3 and Keap1/Nrf2 signaling pathways in the developing rats

Q Hu, H Yan, F Peng, W Feng, F Chen, X Huang… - European Journal of …, 2021 - Elsevier
Background Epilepsy is a common chronic neurological disease. Recurrent seizures can
cause irreversible brain damage. This study aimed to explore the regulation of Genistein on …

Neuronal GPER participates in genistein-mediated neuroprotection in ischemic stroke by inhibiting NLRP3 inflammasome activation in ovariectomized female mice

S Wang, Z Zhang, J Wang, L Ma, J Zhao, J Wang… - Molecular …, 2022 - Springer
Estrogen replacement therapy (ERT) is potentially beneficial for the prevention and
treatment of postmenopausal cerebral ischemia but inevitably increases the risk of cerebral …

Soybean isoflavone ameliorates cognitive impairment, neuroinflammation, and amyloid β accumulation in a rat model of Alzheimer's disease

AE Essawy, HM Abdou, HM Ibrahim… - … Science and Pollution …, 2019 - Springer
Oxidative stress and neuroinflammatory changes appear to be the early events involved in
AD's development and progression. The present study was designed to assess the effect of …

Soy bioactive components in functional perspective: A review

S Garg, VK Lule, RK Malik, SK Tomar - International Journal of …, 2016 - Taylor & Francis
Functional foods are the focus of attraction for well-being. The healthy living of Asians may
be attributed to a diet enriched with soy isoflavones viz. genistein and daidzein which fills …

Therapeutic potential and mechanisms of novel simple o-substituted isoflavones against cerebral ischemia reperfusion

SE Yang, JC Lien, CW Tsai, CR Wu - International Journal of Molecular …, 2022 - mdpi.com
Isoflavones have been widely studied and have attracted extensive attention in fields
ranging from chemotaxonomy and plant physiology to human nutrition and medicine …