The influence of microbiota on ferroptosis in intestinal diseases

T Yao, L Li - Gut Microbes, 2023 - Taylor & Francis
Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by
excessive lipid peroxidation on cellular membranes and compromised cellular antioxidant …

Mechanisms of host adaptation by bacterial pathogens

MF Barber, JR Fitzgerald - FEMS microbiology reviews, 2024 - academic.oup.com
The emergence of new infectious diseases poses a major threat to humans, animals, and
broader ecosystems. Defining factors that govern the ability of pathogens to adapt to new …

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

J Behnsen, H Zhi, AT Aron, V Subramanian… - Nature …, 2021 - nature.com
Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express
the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the …

Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease

M Czech, S Schneider, N Peltokangas… - Science translational …, 2024 - science.org
Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic
hematopoietic cell transplantation (allo-HCT), for which therapeutic options are limited …

DMT1 Protects Macrophages from Salmonella Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression

M Grander, A Hoffmann, M Seifert, E Demetz… - International journal of …, 2022 - mdpi.com
Macrophages are at the center of innate pathogen control and iron recycling. Divalent metal
transporter 1 (DMT1) is essential for the uptake of non-transferrin-bound iron (NTBI) into …

Prebiotics and iron bioavailability? Unveiling the hidden association-A review

AMR Ahmad, W Ahmed, S Iqbal, M Javed… - Trends in Food Science …, 2021 - Elsevier
Background Iron deficiency anemia [IDA] has emerged as public health concern with poor
bioavailability, reliance on dietary cereals and presence of anti-nutritional factors further …

Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice

A Hoffmann, D Haschka, LV de Souza, P Tymoszuk… - …, 2021 - thelancet.com
Background Iron deficiency anaemia (IDA) is a major health concern. However, preventive
iron supplementation in regions with high burden of infectious diseases resulted in an …

Survey of the infant male urobiome and genomic analysis of Actinotignum spp.

SA Reasoner, V Flores, G Van Horn… - npj Biofilms and …, 2023 - nature.com
The urinary bladder harbors a community of microbes termed the urobiome, which remains
understudied. In this study, we present the urobiome of healthy infant males from samples …

Characterizing the pathogenic potential of Crohn's disease-associated adherent-invasive Escherichia coli

MT Zangara, L Darwish, BK Coombes - EcoSal Plus, 2023 - Am Soc Microbiol
The microbiome of Crohn's disease (CD) patients is composed of a microbial community that
is considered dysbiotic and proinflammatory in nature. The overrepresentation of …

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

M Kamel, S Aleya, M Alsubih, L Aleya - Journal of Personalized Medicine, 2024 - mdpi.com
Infectious diseases have long posed a significant threat to global health and require
constant innovation in treatment approaches. However, recent groundbreaking research has …